| 2. Round | 10/06/2021 | Rampla Juniors | - | Racing | 2:2 | ||||
| 3. Round | 16/06/2021 | Villa Teresa | - | Rampla Juniors | 0:1 | ||||
| 4. Round | 25/06/2021 | Rampla Juniors | - | Juventud de Las Piedras | 0:2 |  |
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| 5. Round | 02/07/2021 | Uruguay Montevideo | - | Rampla Juniors | 2:0 | |
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| 7. Round | 15/07/2021 | Rampla Juniors | - | Danubio | 0:0 | ||||
| 8. Round | 22/07/2021 | Rocha | - | Rampla Juniors | 2:0 | |
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| 9. Round | 31/07/2021 | Rampla Juniors | - | CA Cerro | 0:1 | |
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| 12. Round | 15/09/2021 | Rampla Juniors | - | Atenas | 2:1 | |
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| 14. Round | 29/09/2021 | Rampla Juniors | - | Villa Teresa | 0:0 | ||||
| 15. Round | 05/10/2021 | Juventud de Las Piedras | - | Rampla Juniors | 1:1 | |
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| 19. Round | 01/11/2021 | Rampla Juniors | - | Rocha | 2:1 | |
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| 20. Round | 10/11/2021 | CA Cerro | - | Rampla Juniors | 1:2 | ||||
| 21. Round | 18/11/2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | |
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| 22. Round | 25/11/2021 | Central Español | - | Rampla Juniors | 3:0 |
Uruguay