| 4. Round | 08/05/2022 | Vancouver Whitecaps | - | Toronto FC | 1:0 | ||||
| 4. Round | 15/05/2022 | Vancouver Whitecaps | - | San Jose Earthquakes | 3:3 | ||||
| 4. Round | 19/05/2022 | Vancouver Whitecaps | - | FC Dallas | 2:1 | ||||
| 4. Round | 29/05/2022 | Sporting Kansas City | - | Vancouver Whitecaps | 0:1 | ||||
| 5. Round | 05/06/2022 | Vancouver Whitecaps | - | Real Salt Lake | 2:1 | ||||
| 5. Round | 15/06/2022 | Seattle Sounders | - | Vancouver Whitecaps | 4:0 | ||||
| 5. Round | 19/06/2022 | FC Dallas | - | Vancouver Whitecaps | 0:2 |  |
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| 5. Round | 27/06/2022 | Vancouver Whitecaps | - | New England Revolution | 0:0 | ||||
| 6. Round | 03/07/2022 | Vancouver Whitecaps | - | Los Angeles FC | 1:0 | ||||
| 6. Round | 09/07/2022 | Vancouver Whitecaps | - | Minnesota United FC | 1:3 | ||||
| 6. Round | 14/07/2022 | FC Cincinnati | - | Vancouver Whitecaps | 2:2 | ||||
| 6. Round | 31/07/2022 | Nashville SC | - | Vancouver Whitecaps | 1:1 | ||||
| 7. Round | 06/08/2022 | Vancouver Whitecaps | - | Houston Dynamo | 2:1 | ||||
| 7. Round | 14/08/2022 | Los Angeles Galaxy | - | Vancouver Whitecaps | 5:2 | ||||
| 8. Round | 11/09/2022 | Colorado Rapids | - | Vancouver Whitecaps | 3:1 |
USA
England