| 6. Round | 30/09/2021 | El Paso Locomotive | - | Real Monarchs SLC | 1:0 | ||||
| 7. Round | 03/10/2021 | Colorado Springs Switchbacks | - | El Paso Locomotive | 1:1 | ||||
| 7. Round | 07/10/2021 | El Paso Locomotive | - | San Antonio FC | 3:3 | ||||
| 7. Round | 10/10/2021 | FC Tulsa | - | El Paso Locomotive | 1:2 | ||||
| 7. Round | 14/10/2021 | El Paso Locomotive | - | Colorado Springs Switchbacks | 4:2 | ||||
| 7. Round | 18/10/2021 | Los Angeles Galaxy II | - | El Paso Locomotive | 5:0 | ||||
| 7. Round | 21/10/2021 | El Paso Locomotive | - | Austin Bold | 3:0 | ||||
| 7. Round | 25/10/2021 | El Paso Locomotive | - | OKC Energy FC | 4:0 | ||||
| 7. Round | 31/10/2021 | Rio Grande Valley FC | - | El Paso Locomotive | 4:1 |
USA