| 1. Round | 08/01/2022 | Pumas UNAM [U16] | - | Cruz Azul [U16] | 1:2 | ||||
| 2. Round | 15/01/2022 | Cruz Azul [U16] | - | CF Pachuca [U16] | 4:2 | ||||
| 3. Round | 22/01/2022 | Club Necaxa [U16] | - | Cruz Azul [U16] | 2:1 | ||||
| 4. Round | 29/01/2022 | Cruz Azul [U16] | - | Gallos Blancos [U16] | 2:0 | ||||
| 5. Round | 05/02/2022 | Deportivo Toluca [U16] | - | Cruz Azul [U16] | 0:4 |  |
 |
||
| 7. Round | 19/02/2022 | FC Juárez [U16] | - | Cruz Azul [U16] | 1:2 | |
|||
| 8. Round | 26/02/2022 | Cruz Azul [U16] | - | Puebla FC [U16] | 1:2 | ||||
| 9. Round | 05/03/2022 | Cruz Azul [U16] | - | CF América [U16] | 3:2 | |
|||
| 10. Round | 12/03/2022 | CF Pachuca [U16] | - | Cruz Azul [U16] | 2:2 | ||||
| 15. Round | 23/03/2022 | Cruz Azul [U16] | - | Pumas UNAM [U16] | 0:2 | ||||
| 12. Round | 26/03/2022 | Cruz Azul [U16] | - | FC Juárez [U16] | 7:3 | ||||
| 13. Round | 02/04/2022 | Cruz Azul [U16] | - | Deportivo Toluca [U16] | 0:1 | ||||
| 16. Round | 23/04/2022 | Puebla FC [U16] | - | Cruz Azul [U16] | 2:3 | ||||
| 14. Round | 27/04/2022 | CF América [U16] | - | Cruz Azul [U16] | 1:0 | ||||
| 18. Round | 07/05/2022 | Cruz Azul [U16] | - | Club Necaxa [U16] | 2:4 |
Mexico