| 6. Round | 11/03/2022 | Sportivo Ameliano | - | Tacuary | 0:2 |  |
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| 7. Round | 21/03/2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 8. Round | 04/04/2022 | Guaraní | - | Tacuary | 1:2 | ||||
| 9. Round | 11/04/2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
| 10. Round | 19/04/2022 | Sol de América | - | Tacuary | 1:0 | ||||
| 11. Round | 21/04/2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
| 12. Round | 25/04/2022 | Tacuary | - | Resistencia SC | 3:1 | ||||
| 13. Round | 30/04/2022 | 12 de Octubre de Itauguá | - | Tacuary | 2:0 | ||||
| 14. Round | 07/05/2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
| 15. Round | 11/05/2022 | Libertad | - | Tacuary | 3:0 | ||||
| 16. Round | 16/05/2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 17. Round | 20/05/2022 | Tacuary | - | Sportivo Ameliano | 1:0 | |
 |
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| 18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 | |
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| 19. Round | 19/06/2022 | Tacuary | - | Guaraní | 0:2 | ||||
| 20. Round | 24/06/2022 | Guaireña FC | - | Tacuary | 0:0 | ||||
| 21. Round | 28/06/2022 | Tacuary | - | Sol de América | 2:2 | ||||
| 22. Round | 02/07/2022 | Cerro Porteño | - | Tacuary | 1:0 |
Paraguay