| 1. Round | 27/08/2022 | Colima FC | - | Saltillo FC | 1:1 |  |
|||
| 3. Round | 08/09/2022 | Tulancingo | - | Saltillo FC | 0:2 | ||||
| 4. Round | 11/09/2022 | Saltillo FC | - | Lobos ULMX | 3:1 | ||||
| 5. Round | 18/09/2022 | Saltillo FC | - | Catedráticos Elite | 3:0 |  |
|||
| 2. Round | 21/09/2022 | Aguacateros CDU | - | Saltillo FC | 4:1 | ||||
| 6. Round | 25/09/2022 | Reboceros de La Piedad | - | Saltillo FC | 1:0 | |
|||
| 8. Round | 02/10/2022 | Tampico Madero | - | Saltillo FC | 3:0 | ||||
| 9. Round | 08/10/2022 | Saltillo FC | - | Inter de Querétaro | 3:1 | ||||
| 10. Round | 15/10/2022 | Correcaminos UAT II | - | Saltillo FC | 0:2 | |
|||
| 11. Round | 22/10/2022 | Saltillo FC | - | Gavilanes de Matamoros | 1:1 |
Mexico