| 1. Round | 07/08/2005 | River Plate | - | Tiro Federal de Rosario | 2:0 | ||||
| 2. Round | 14/08/2005 | Gimnasia de Jujuy | - | River Plate | 0:0 | ||||
| 3. Round | 21/08/2005 | River Plate | - | Newell's Old Boys | 2:1 | ||||
| 4. Round | 28/08/2005 | Banfield | - | River Plate | 4:1 | ||||
| 5. Round | 07/09/2005 | River Plate | - | Colón de Santa Fe | 3:2 | ||||
| 7. Round | 18/09/2005 | River Plate | - | Vélez Sarsfield | 0:1 |  |
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| 8. Round | 25/09/2005 | Estudiantes | - | River Plate | 1:0 | ||||
| 11. Round | 16/10/2005 | River Plate | - | Boca Juniors | 0:0 | ||||
| 12. Round | 30/10/2005 | Rosario Central | - | River Plate | 0:3 | ||||
| 13. Round | 09/11/2005 | River Plate | - | Lanús | 4:1 | ||||
| 14. Round | 13/11/2005 | Instituto de Córdoba | - | River Plate | 1:4 | ||||
| 15. Round | 17/11/2005 | River Plate | - | San Lorenzo | 5:1 | ||||
| 17. Round | 27/11/2005 | River Plate | - | Gimnasia de La Plata | 1:3 | ||||
| 18. Round | 04/12/2005 | Racing Club | - | River Plate | 1:1 | |
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| 19. Round | 11/12/2005 | River Plate | - | Quilmes | 1:1 |
Chile