| 1. Round | 23/02/2025 | San Jose Earthquakes | - | Real Salt Lake | 4:0 | ||||
| 2. Round | 02/03/2025 | Sporting Kansas City | - | San Jose Earthquakes | 1:2 |  |
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| 3. Round | 09/03/2025 | San Jose Earthquakes | - | Minnesota United FC | 0:1 | ||||
| 4. Round | 16/03/2025 | San Jose Earthquakes | - | Colorado Rapids | 1:2 | |
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| 5. Round | 22/03/2025 | Charlotte FC | - | San Jose Earthquakes | 4:1 | |
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| 6. Round | 30/03/2025 | San Jose Earthquakes | - | Seattle Sounders | 1:1 | ||||
| 7. Round | 06/04/2025 | San Jose Earthquakes | - | D.C. United | 6:1 | |
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| 8. Round | 13/04/2025 | Los Angeles FC | - | San Jose Earthquakes | 2:1 | ||||
| 9. Round | 20/04/2025 | San Jose Earthquakes | - | Sporting Kansas City | 3:5 | |
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| 10. Round | 27/04/2025 | Columbus Crew | - | San Jose Earthquakes | 2:1 | ||||
| 11. Round | 04/05/2025 | San Jose Earthquakes | - | Portland Timbers | 4:1 | |
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| 12. Round | 11/05/2025 | Colorado Rapids | - | San Jose Earthquakes | 0:2 | |
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| 13. Round | 15/05/2025 | San Jose Earthquakes | - | Inter Miami CF | 3:3 | |
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| 18. Round | 14/06/2025 | Portland Timbers | - | San Jose Earthquakes | 1:1 | ||||
| 19. Round | 26/06/2025 | FC Dallas | - | San Jose Earthquakes | 2:4 | |
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Colombia