| 1. Round | 06/02/2022 | Albion | - | Rentistas | 3:5 | ||||
| 2. Round | 13/02/2022 | Liverpool | - | Albion | 4:0 | ||||
| 3. Round | 19/02/2022 | Albion | - | Peñarol | 1:1 | ||||
| 4. Round | 28/02/2022 | Montevideo City Torque | - | Albion | 1:2 |  |
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| 5. Round | 13/03/2022 | Albion | - | Montevideo Wanderers | 1:1 | ||||
| 6. Round | 19/03/2022 | Plaza Colonia | - | Albion | 1:1 |  |
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| 7. Round | 02/04/2022 | Albion | - | Boston River | 1:2 | ||||
| 8. Round | 10/04/2022 | River Plate | - | Albion | 4:1 | ||||
| 9. Round | 16/04/2022 | Albion | - | Cerro Largo | 2:1 | ||||
| 10. Round | 24/04/2022 | Fénix | - | Albion | 2:1 | ||||
| 11. Round | 07/05/2022 | Albion | - | Defensor Sporting | 0:3 | ||||
| 12. Round | 15/05/2022 | Albion | - | Cerrito | 2:2 | ||||
| 14. Round | 27/05/2022 | Albion | - | Danubio | 1:2 | ||||
| 15. Round | 04/06/2022 | Deportivo Maldonado | - | Albion | 0:0 | |
Uruguay