| 1. Round | 17/07/2016 | CF Monterrey | - | Puebla FC | 1:1 | ||||
| 2. Round | 25/07/2016 | Puebla FC | - | Club Tijuana | 3:2 | ||||
| 3. Round | 30/07/2016 | Gallos Blancos | - | Puebla FC | 2:1 | ||||
| 4. Round | 08/08/2016 | Puebla FC | - | Santos Laguna | 0:0 | ||||
| 5. Round | 14/08/2016 | Atlas Guadalajara | - | Puebla FC | 3:2 | ||||
| 6. Round | 22/08/2016 | Puebla FC | - | CF América | 2:2 |  |
|||
| 7. Round | 28/08/2016 | Chiapas FC | - | Puebla FC | 0:3 | ||||
| 8. Round | 12/09/2016 | Puebla FC | - | Deportivo Toluca | 0:2 | ||||
| 9. Round | 18/09/2016 | UANL Tigres | - | Puebla FC | 2:1 | |
|||
| 10. Round | 21/09/2016 | Puebla FC | - | CD Veracruz | 3:2 | ||||
| 11. Round | 25/09/2016 | Monarcas Morelia | - | Puebla FC | 2:3 | ||||
| 12. Round | 03/10/2016 | Puebla FC | - | CF Pachuca | 1:1 | |
|||
| 13. Round | 17/10/2016 | Puebla FC | - | Deportivo Guadalajara | 0:2 | |
|||
| 14. Round | 22/10/2016 | Cruz Azul | - | Puebla FC | 1:2 | ||||
| 15. Round | 31/10/2016 | Puebla FC | - | Club León | 2:2 | ||||
| 16. Round | 06/11/2016 | Club Necaxa | - | Puebla FC | 3:1 | ||||
| 17. Round | 21/11/2016 | Puebla FC | - | Pumas UNAM | 0:3 |
Argentina
Italy