| 3. Round | 02/03/2021 | Rosario Central | - | Godoy Cruz | 2:2 | ||||
| 4. Round | 06/03/2021 | Godoy Cruz | - | Platense | 3:1 |  |
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| 5. Round | 13/03/2021 | Argentinos Juniors | - | Godoy Cruz | 2:0 | ||||
| 6. Round | 21/03/2021 | Godoy Cruz | - | River Plate | 1:6 | ||||
| 7. Round | 28/03/2021 | Talleres de Córdoba | - | Godoy Cruz | 1:1 | ||||
| 8. Round | 05/04/2021 | Racing Club | - | Godoy Cruz | 2:4 |  |
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| 9. Round | 11/04/2021 | Godoy Cruz | - | Arsenal de Sarandí | 2:3 | ||||
| 11. Round | 24/04/2021 | Godoy Cruz | - | Central Córdoba SdE | 1:0 | ||||
| 12. Round | 02/05/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 13. Round | 08/05/2021 | Godoy Cruz | - | Banfield | 0:1 |
Paraguay