| 3. Round | 27/02/2022 | Deportes Iquique | - | Deportes Temuco | 1:0 | ||||
| 4. Round | 08/03/2022 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 5. Round | 15/03/2022 | Deportes Iquique | - | CD Magallanes | 1:1 | ||||
| 6. Round | 22/03/2022 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 7. Round | 03/04/2022 | Deportes Iquique | - | Santa Cruz | 2:2 | ||||
| 8. Round | 08/04/2022 | Fernández Vial | - | Deportes Iquique | 0:0 | ||||
| 9. Round | 17/04/2022 | Deportes Iquique | - | Cobreloa | 2:0 | ||||
| 10. Round | 19/04/2022 | Deportes Copiapó | - | Deportes Iquique | 1:0 | ||||
| 11. Round | 24/04/2022 | Deportes Iquique | - | Rangers | 0:2 | ||||
| 12. Round | 30/04/2022 | Universidad de Concepción | - | Deportes Iquique | 2:2 | ||||
| 13. Round | 07/05/2022 | Deportes Iquique | - | San Luis | 1:1 |  |
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| 14. Round | 11/05/2022 | Barnechea | - | Deportes Iquique | 6:2 | ||||
| 16. Round | 21/05/2022 | Unión San Felipe | - | Deportes Iquique | 2:0 | ||||
| 17. Round | 29/05/2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 1. Round | 05/06/2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 |  |
Argentina