| 2. Round | 21/01/2021 | Montevideo Wanderers | - | Danubio | 2:0 | ||||
| 4. Round | 04/02/2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Round | 07/02/2021 | Danubio | - | Montevideo City Torque | 0:4 | ||||
| 6. Round | 10/02/2021 | Plaza Colonia | - | Danubio | 3:0 |  |
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| 7. Round | 15/02/2021 | Danubio | - | Progreso | 0:1 | ||||
| 9. Round | 22/02/2021 | Danubio | - | CA Cerro | 2:1 | ||||
| 10. Round | 28/02/2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 12. Round | 13/03/2021 | Danubio | - | Nacional | 2:1 | ||||
| 13. Round | 19/03/2021 | Boston River | - | Danubio | 1:5 | ||||
| 14. Round | 23/03/2021 | Danubio | - | Deportivo Maldonado | 2:2 |
Uruguay