| 3. Round | 21/01/2023 | Santos Laguna [U16] | - | CF Monterrey [U16] | 2:0 | ||||
| 5. Round | 04/02/2023 | Santos Laguna [U16] | - | Club León [U16] | 4:0 | ||||
| 6. Round | 11/02/2023 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 1:0 | ||||
| 7. Round | 18/02/2023 | Club Tijuana [U16] | - | Santos Laguna [U16] | 1:2 |  |
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| 8. Round | 25/02/2023 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 1:0 | ||||
| 9. Round | 04/03/2023 | UANL Tigres [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 10. Round | 11/03/2023 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 3:2 | ||||
| 13. Round | 30/03/2023 | Santos Laguna [U16] | - | UANL Tigres [U16] | 1:0 | ||||
| 14. Round | 08/04/2023 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 2:0 | |
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| 15. Round | 15/04/2023 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 2:0 | |
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| 16. Round | 22/04/2023 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 1:1 | |
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| 18. Round | 06/05/2023 | Santos Laguna [U16] | - | Club Tijuana [U16] | 1:0 |
Mexico