| 1. Round | 30/04/2022 | Villa Española | - | Rampla Juniors | 3:2 | ||||
| 2. Round | 08/05/2022 | Rampla Juniors | - | Juventud de Las Piedras | 0:1 | ||||
| 3. Round | 15/05/2022 | Racing | - | Rampla Juniors | 1:0 |  |
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| 4. Round | 21/05/2022 | Rampla Juniors | - | Uruguay Montevideo | 1:2 | ||||
| 5. Round | 25/05/2022 | Rampla Juniors | - | Progreso | 1:1 |  |
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| 12. Round | 24/07/2022 | Rampla Juniors | - | Villa Española | 1:0 | ||||
| 13. Round | 31/07/2022 | Juventud de Las Piedras | - | Rampla Juniors | 1:2 | ||||
| 14. Round | 07/08/2022 | Rampla Juniors | - | Racing | 1:0 | |
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| 15. Round | 13/08/2022 | Uruguay Montevideo | - | Rampla Juniors | 0:4 |  |
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| 16. Round | 20/08/2022 | Progreso | - | Rampla Juniors | 0:1 | ||||
| 17. Round | 23/08/2022 | Rampla Juniors | - | La Luz | 0:3 | ||||
| 18. Round | 29/08/2022 | Atenas | - | Rampla Juniors | 1:1 | ||||
| 19. Round | 03/09/2022 | Rampla Juniors | - | CA Cerro | 2:2 | |
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| 20. Round | 11/09/2022 | Sud América | - | Rampla Juniors | 2:1 | ||||
| 21. Round | 18/09/2022 | Rampla Juniors | - | Central Español | 3:0 | |
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| 22. Round | 25/09/2022 | Miramar Misiones | - | Rampla Juniors | 1:3 | |
Uruguay