| 15. Round | 07/02/2021 | Leones Negros II | - | Atlético San Luis II | 1:2 |  |
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| 16. Round | 13/02/2021 | Atlético San Luis II | - | Tecos Fútbol Club | 1:2 | ||||
| 18. Round | 05/03/2021 | Atlético San Luis II | - | Mazorqueros | 2:1 | ||||
| 19. Round | 14/03/2021 | Colima FC | - | Atlético San Luis II | 2:0 | ||||
| 20. Round | 21/03/2021 | Reboceros de La Piedad | - | Atlético San Luis II | 1:0 | ||||
| 22. Round | 10/04/2021 | Tuzos de la UAZ | - | Atlético San Luis II | 1:0 |
Mexico