| 11. Round | 02/02/2022 | Ergotelis | - | PAE Chania | 0:0 |  |
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| 17. Round | 06/02/2022 | PAE Chania | - | GS Kallithea | 0:0 | ||||
| 12. Round | 09/02/2022 | PAE Chania | - | Asteras Vlachioti | 3:1 | ||||
| 18. Round | 13/02/2022 | PAE Chania | - | AO Egaleo | 1:0 | |
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| 19. Round | 16/02/2022 | Irodotos | - | PAE Chania | 2:2 | ||||
| 20. Round | 20/02/2022 | PAE Chania | - | Levadiakos | 3:1 | ||||
| 21. Round | 27/02/2022 | AS Rhodos | - | PAE Chania | 0:1 | ||||
| 22. Round | 06/03/2022 | PAE Chania | - | AO Episkopi | 1:0 | |
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| 23. Round | 09/03/2022 | AE Kifisias | - | PAE Chania | 1:0 | ||||
| 26. Round | 26/03/2022 | PAE Chania | - | Panathinaikos II | 2:0 | ||||
| 27. Round | 30/03/2022 | AE Karaiskakis | - | PAE Chania | 1:2 | ||||
| 28. Round | 03/04/2022 | PAE Chania | - | Ergotelis | 0:0 | ||||
| 29. Round | 06/04/2022 | Asteras Vlachioti | - | PAE Chania | 0:0 | ||||
| 30. Round | 10/04/2022 | PAE Chania | - | Diagoras FC | 2:0 | ||||
| 32. Round | 17/04/2022 | APS Zakynthos | - | PAE Chania | 3:1 |  |
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| 34. Round | 01/05/2022 | GS Kallithea | - | PAE Chania | 3:1 |
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