| 4. Round | 28/01/2023 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 6. Round | 11/02/2023 | Deportivo Guadalajara [] | - | Santos Laguna [] | 0:0 | ||||
| 8. Round | 24/02/2023 | Deportivo Guadalajara [] | - | Club León [] | 2:1 |  |
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| 9. Round | 04/03/2023 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 10. Round | 11/03/2023 | CF Monterrey [] | - | Deportivo Guadalajara [] | 3:1 | ||||
| 11. Round | 19/03/2023 | Deportivo Guadalajara [] | - | Club Tijuana [] | 1:4 | ||||
| 12. Round | 25/03/2023 | Club León [] | - | Deportivo Guadalajara [] | 2:2 | ||||
| 15. Round | 15/04/2023 | Santos Laguna [] | - | Deportivo Guadalajara [] | 5:3 | ||||
| 16. Round | 22/04/2023 | Deportivo Guadalajara [] | - | UANL Tigres [] | 3:2 |
Mexico