| 1. Round | 04/04/2021 | CD Magallanes | - | San Marcos | 1:3 | ||||
| 2. Round | 18/04/2021 | San Marcos | - | Cobreloa | 0:0 | ||||
| 3. Round | 25/04/2021 | Deportes Iquique | - | San Marcos | 1:2 | ||||
| 5. Round | 10/05/2021 | Santiago Morning | - | San Marcos | 3:0 | ||||
| 6. Round | 18/05/2021 | San Marcos | - | Deportes Temuco | 1:2 |  |
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| 7. Round | 24/05/2021 | Coquimbo Unido | - | San Marcos | 1:0 | ||||
| 8. Round | 01/06/2021 | San Marcos | - | Unión San Felipe | 3:1 | ||||
| 10. Round | 09/07/2021 | San Marcos | - | Deportes Copiapó | 0:1 | ||||
| 22. Round | 28/09/2021 | San Marcos | - | Coquimbo Unido | 0:0 | |
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| 23. Round | 03/10/2021 | Unión San Felipe | - | San Marcos | 0:0 | ||||
| 24. Round | 08/10/2021 | San Marcos | - | San Luis | 1:2 | |
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| 26. Round | 22/10/2021 | San Marcos | - | Puerto Montt | 1:2 | ||||
| 27. Round | 27/10/2021 | Barnechea | - | San Marcos | 1:1 | ||||
| 28. Round | 31/10/2021 | San Marcos | - | Universidad de Concepción | 0:0 |
Chile