| 8. Round | 08/04/2022 | Fernández Vial | - | Deportes Iquique | 0:0 | ||||
| 10. Round | 19/04/2022 | Deportes Copiapó | - | Deportes Iquique | 1:0 | ||||
| 11. Round | 24/04/2022 | Deportes Iquique | - | Rangers | 0:2 | ||||
| 15. Round | 15/05/2022 | Deportes Iquique | - | Recoleta | 2:1 |  |
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| 16. Round | 21/05/2022 | Unión San Felipe | - | Deportes Iquique | 2:0 | ||||
| 17. Round | 29/05/2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 1. Round | 05/06/2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 |  |
Chile