| 1. Round | 21/09/2020 | Cimarrones de Sonora II | - | Mazorqueros | 1:2 | ||||
| 2. Round | 25/09/2020 | Mazorqueros | - | Saltillo FC | 1:1 | ||||
| 3. Round | 04/10/2020 | Leones Negros II | - | Mazorqueros | 1:2 | ||||
| 4. Round | 12/10/2020 | Mazorqueros | - | Tecos Fútbol Club | 2:0 | ||||
| 5. Round | 17/10/2020 | Mineros de Fresnillo FC | - | Mazorqueros | 3:1 | ||||
| 6. Round | 24/10/2020 | Mazorqueros | - | Colima FC | 0:2 | ||||
| 7. Round | 09/11/2020 | Mazorqueros | - | Atlético San Luis II | 1:0 | ||||
| 9. Round | 22/11/2020 | Mazorqueros | - | Gavilanes de Matamoros | 1:2 | ||||
| 10. Round | 06/12/2020 | Tuzos de la UAZ | - | Mazorqueros | 3:1 | ||||
| 12. Round | 16/01/2021 | Mazorqueros | - | Cimarrones de Sonora II | 1:1 | ||||
| 13. Round | 23/01/2021 | Saltillo FC | - | Mazorqueros | 3:2 | ||||
| 14. Round | 29/01/2021 | Mazorqueros | - | Leones Negros II | 1:0 | ||||
| 15. Round | 08/02/2021 | Tecos Fútbol Club | - | Mazorqueros | 3:1 | ||||
| 20. Round | 20/03/2021 | Gavilanes de Matamoros | - | Mazorqueros | 1:0 | ||||
| 21. Round | 02/04/2021 | Mazorqueros | - | Tuzos de la UAZ | 3:0 | ||||
| 22. Round | 10/04/2021 | Alacranes de Durango | - | Mazorqueros | 4:0 |
Mexico