| 1. Round | 18/09/2020 | Inter Playa | - | Cafessa Jalisco | 2:1 |  |
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| 2. Round | 27/09/2020 | Cafessa Jalisco | - | Cafetaleros de Chiapas | 3:3 | |
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| 4. Round | 10/10/2020 | Cafessa Jalisco | - | Azores de Hidalgo | 0:0 | |
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| 6. Round | 25/10/2020 | Cafessa Jalisco | - | Club Irapuato | 4:3 | |
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| 7. Round | 02/11/2020 | Club de Ciervos | - | Cafessa Jalisco | 0:5 | ||||
| 8. Round | 08/11/2020 | Cafessa Jalisco | - | Cañoneros Marina | 1:0 | ||||
| 9. Round | 15/11/2020 | Cruz Azul Hidalgo | - | Cafessa Jalisco | 0:1 | |
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| 3. Round | 16/12/2020 | Zitácuaro | - | Cafessa Jalisco | 1:3 | ||||
| 14. Round | 17/01/2021 | Cafessa Jalisco | - | Inter Playa | 0:2 | |
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| 16. Round | 02/02/2021 | Cafessa Jalisco | - | Zitácuaro | 2:0 | ||||
| 17. Round | 07/02/2021 | Azores de Hidalgo | - | Cafessa Jalisco | 2:0 | ||||
| 22. Round | 14/03/2021 | Cafessa Jalisco | - | Cruz Azul Hidalgo | 1:3 | ||||
| 23. Round | 21/03/2021 | CD Cuautla | - | Cafessa Jalisco | 0:2 | |
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| 24. Round | 01/04/2021 | Cafessa Jalisco | - | Deportivo Dongu | 1:0 | |
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| 25. Round | 03/04/2021 | Aguacateros CDU | - | Cafessa Jalisco | 1:0 |  |
Mexico