| 1. Round | 09/08/2015 | Newcastle United | - | Southampton FC | 2:2 | ||||
| 4. Round | 30/08/2015 | Southampton FC | - | Norwich City | 3:0 | ||||
| 6. Round | 20/09/2015 | Southampton FC | - | Manchester United | 2:3 | ||||
| 18. Round | 26/12/2015 | Southampton FC | - | Arsenal FC | 4:0 |  |
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| 19. Round | 28/12/2015 | West Ham United | - | Southampton FC | 2:1 |  |
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| 20. Round | 02/01/2016 | Norwich City | - | Southampton FC | 1:0 | ||||
| 22. Round | 16/01/2016 | Southampton FC | - | West Bromwich Albion | 3:0 | ||||
| 29. Round | 05/03/2016 | Southampton FC | - | Sunderland AFC | 1:1 | ||||
| 30. Round | 12/03/2016 | Stoke City | - | Southampton FC | 1:2 | ||||
| 31. Round | 20/03/2016 | Southampton FC | - | Liverpool FC | 3:2 | ||||
| 33. Round | 09/04/2016 | Southampton FC | - | Newcastle United | 3:1 | ||||
| 34. Round | 16/04/2016 | Everton FC | - | Southampton FC | 1:1 | ||||
| 36. Round | 01/05/2016 | Southampton FC | - | Manchester City | 4:2 | ||||
| 37. Round | 08/05/2016 | Tottenham Hotspur | - | Southampton FC | 1:2 | ||||
| 38. Round | 15/05/2016 | Southampton FC | - | Crystal Palace | 4:1 |
Netherlands
