| 5. Round | 18/09/2016 | Southampton FC | - | Swansea City | 1:0 | ||||
| 6. Round | 25/09/2016 | West Ham United | - | Southampton FC | 0:3 | ||||
| 7. Round | 02/10/2016 | Leicester City | - | Southampton FC | 0:0 | ||||
| 8. Round | 16/10/2016 | Southampton FC | - | Burnley FC | 3:1 | ||||
| 9. Round | 23/10/2016 | Manchester City | - | Southampton FC | 1:1 | ||||
| 10. Round | 30/10/2016 | Southampton FC | - | Chelsea FC | 0:2 | ||||
| 15. Round | 11/12/2016 | Southampton FC | - | Middlesbrough FC | 1:0 | ||||
| 16. Round | 14/12/2016 | Stoke City | - | Southampton FC | 0:0 | ||||
| 19. Round | 31/12/2016 | Southampton FC | - | West Bromwich Albion | 1:2 |
Netherlands
