| 4. Round | 04/07/2021 | Minnesota United FC | - | San Jose Earthquakes | 2:2 | ||||
| 4. Round | 08/07/2021 | Colorado Rapids | - | Minnesota United FC | 2:0 | ||||
| 4. Round | 18/07/2021 | Minnesota United FC | - | Seattle Sounders | 1:0 | ||||
| 4. Round | 29/07/2021 | Los Angeles FC | - | Minnesota United FC | 2:2 | ||||
| 5. Round | 01/08/2021 | Vancouver Whitecaps | - | Minnesota United FC | 2:2 |  |
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| 5. Round | 18/08/2021 | San Jose Earthquakes | - | Minnesota United FC | 1:1 | |
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| 6. Round | 16/09/2021 | Sporting Kansas City | - | Minnesota United FC | 4:0 | ||||
| 7. Round | 10/10/2021 | Minnesota United FC | - | Colorado Rapids | 1:3 |
USA