| 3. Round | 02/04/2022 | NEC Nijmegen [U21] | - | PEC Zwolle [U21] | 0:2 | ||||
| 4. Round | 09/04/2022 | NEC Nijmegen [U21] | - | ADO Den Haag [U21] | 0:3 | ||||
| 5. Round | 23/04/2022 | Almere City FC [U21] | - | NEC Nijmegen [U21] | 4:1 | ||||
| 7. Round | 14/05/2022 | NAC Breda [U21] | - | NEC Nijmegen [U21] | 1:6 |  |
Netherlands