| 7. Round | 14/09/2020 | Villa Teresa | - | Villa Española | 0:1 | ||||
| 8. Round | 18/09/2020 | Villa Española | - | Juventud de Las Piedras | 2:2 | ||||
| 9. Round | 21/09/2020 | Racing | - | Villa Española | 2:3 | ||||
| 12. Round | 09/10/2020 | Albion | - | Villa Española | 1:2 | ||||
| 13. Round | 12/10/2020 | Villa Española | - | Rocha | 3:0 | ||||
| 14. Round | 19/10/2020 | Villa Española | - | Sud América | 1:0 |  |
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| 15. Round | 27/10/2020 | Atenas | - | Villa Española | 1:1 | ||||
| 16. Round | 30/10/2020 | Villa Española | - | Central Español | 1:1 | |
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| 18. Round | 10/11/2020 | Villa Española | - | Villa Teresa | 3:0 | ||||
| 19. Round | 17/11/2020 | Juventud de Las Piedras | - | Villa Española | 0:0 | ||||
| 20. Round | 20/11/2020 | Villa Española | - | Racing | 0:2 | ||||
| 21. Round | 24/11/2020 | Cerrito | - | Villa Española | 1:1 |
Uruguay