| 1. Round | 08/02/2022 | Cerrito | - | Danubio | 0:1 | ||||
| 2. Round | 13/02/2022 | Boston River | - | Cerrito | 0:1 | ||||
| 3. Round | 21/02/2022 | Cerrito | - | Deportivo Maldonado | 0:3 | ||||
| 4. Round | 28/02/2022 | River Plate | - | Cerrito | 3:1 | ||||
| 5. Round | 11/03/2022 | Cerrito | - | Rentistas | 0:3 dec. | ||||
| 7. Round | 03/04/2022 | Cerrito | - | Liverpool | 0:1 | ||||
| 10. Round | 26/04/2022 | Defensor Sporting | - | Cerrito | 0:0 |
Uruguay