4. Round | 15/08/2021 | Club León | - | Mazatlán FC | 3:0 | ||||
9. Round | 19/09/2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
11. Round | 29/09/2021 | Mazatlán FC | - | FC Juárez | 3:1 | ||||
12. Round | 03/10/2021 | Santos Laguna | - | Mazatlán FC | 1:0 | ||||
13. Round | 16/10/2021 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | ||||
14. Round | 20/10/2021 | Puebla FC | - | Mazatlán FC | 2:0 | ||||
15. Round | 23/10/2021 | Mazatlán FC | - | Gallos Blancos | 2:1 | ||||
16. Round | 30/10/2021 | Club Necaxa | - | Mazatlán FC | 2:1 | ||||
17. Round | 06/11/2021 | Mazatlán FC | - | Deportivo Guadalajara | 0:1 |