| 12. Round | 01/08/2021 | Real Tomayapo | - | Oriente Petrolero | 0:1 | ||||
| 15. Round | 14/08/2021 | Atlético Palmaflor | - | Real Tomayapo | 2:0 | ||||
| 16. Round | 17/08/2021 | Always Ready | - | Real Tomayapo | 3:1 | ||||
| 17. Round | 22/08/2021 | Real Tomayapo | - | Royal Pari | 1:4 | ||||
| 18. Round | 12/09/2021 | Real Potosí | - | Real Tomayapo | 1:0 |  |
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| 19. Round | 18/09/2021 | Real Tomayapo | - | CD Guabirá | 1:1 | ||||
| 20. Round | 22/09/2021 | Blooming | - | Real Tomayapo | 0:1 | ||||
| 22. Round | 17/10/2021 | Club Aurora | - | Real Tomayapo | 1:2 | ||||
| 24. Round | 27/10/2021 | Real Tomayapo | - | Club San José | 1:0 | ||||
| 25. Round | 01/11/2021 | Real Santa Cruz | - | Real Tomayapo | 2:0 | ||||
| 27. Round | 27/11/2021 | Oriente Petrolero | - | Real Tomayapo | 3:1 | ||||
| 29. Round | 06/12/2021 | Jorge Wilstermann | - | Real Tomayapo | 3:0 |
Bolivia
Spain