| 3. Round | 17/08/2021 | AFC Wimbledon | - | Gillingham FC | 1:1 | ||||
| 8. Round | 18/09/2021 | AFC Wimbledon | - | Plymouth Argyle | 0:1 | ||||
| 10. Round | 28/09/2021 | Rotherham United | - | AFC Wimbledon | 3:0 | ||||
| 16. Round | 30/10/2021 | Cambridge United | - | AFC Wimbledon | 1:0 | ||||
| 18. Round | 20/11/2021 | Portsmouth FC | - | AFC Wimbledon | 2:1 | ||||
| 19. Round | 23/11/2021 | AFC Wimbledon | - | Crewe Alexandra | 3:2 | ||||
| 20. Round | 27/11/2021 | AFC Wimbledon | - | Fleetwood Town | 2:2 | ||||
| 21. Round | 07/12/2021 | Accrington Stanley | - | AFC Wimbledon | 0:2 | ||||
| 25. Round | 29/12/2021 | Oxford United | - | AFC Wimbledon | 3:0 |  |
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| 23. Round | 18/01/2022 | AFC Wimbledon | - | Portsmouth FC | 0:0 | ||||
| 27. Round | 25/01/2022 | AFC Wimbledon | - | Ipswich Town | 0:2 | ||||
| 32. Round | 08/02/2022 | AFC Wimbledon | - | Rotherham United | 0:1 | ||||
| 37. Round | 05/03/2022 | Wigan Athletic | - | AFC Wimbledon | 1:0 | ||||
| 26. Round | 08/03/2022 | Plymouth Argyle | - | AFC Wimbledon | 2:0 | ||||
| 41. Round | 02/04/2022 | Sheffield Wednesday | - | AFC Wimbledon | 2:1 | |
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| 24. Round | 05/04/2022 | AFC Wimbledon | - | Charlton Athletic | 1:1 | ||||
| 46. Round | 30/04/2022 | AFC Wimbledon | - | Accrington Stanley | 3:4 |
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