| 2. Round | 21/01/2021 | TM Fútbol Club | - | Leones Negros | 0:0 | ||||
| 3. Round | 29/01/2021 | Leones Negros | - | Dorados de Sinaloa | 0:1 | ||||
| 4. Round | 03/02/2021 | Pumas Tabasco | - | Leones Negros | 2:0 | ||||
| 5. Round | 12/02/2021 | Leones Negros | - | Venados FC | 1:1 |  |
|||
| 6. Round | 17/02/2021 | Correcaminos UAT | - | Leones Negros | 0:2 |  |
|||
| 7. Round | 25/02/2021 | Leones Negros | - | Atlante | 0:3 | ||||
| 8. Round | 04/03/2021 | Tapatío | - | Leones Negros | 2:1 | ||||
| 9. Round | 12/03/2021 | Leones Negros | - | Cimarrones de Sonora | 1:1 |  |
|||
| 13. Round | 02/04/2021 | Leones Negros | - | Club Celaya | 3:1 | ||||
| 15. Round | 14/04/2021 | Leones Negros | - | Alebrijes de Oaxaca | 1:1 |
Mexico