| 1. Round | 17/09/2021 | Inter Playa | - | Yalmakan FC | 3:0 |  |
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| 2. Round | 25/09/2021 | Cafetaleros de Chiapas | - | Inter Playa | 3:2 | ||||
| 3. Round | 01/10/2021 | Inter Playa | - | Lobos ULMX | 3:1 | ||||
| 4. Round | 08/10/2021 | CD Zap | - | Inter Playa | 1:5 | ||||
| 5. Round | 13/10/2021 | Inter Playa | - | Reboceros de La Piedad | 1:1 | |
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| 6. Round | 16/10/2021 | Inter de Querétaro | - | Inter Playa | 0:0 | |
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| 7. Round | 22/10/2021 | Inter Playa | - | Deportivo Dongu | 1:0 | ||||
| 8. Round | 31/10/2021 | Montañeses FC | - | Inter Playa | 1:1 | ||||
| 9. Round | 05/11/2021 | Inter Playa | - | Cañoneros FC | 3:0 dec. | ||||
| 10. Round | 10/11/2021 | Leviatán FC | - | Inter Playa | 0:5 | ||||
| 12. Round | 19/11/2021 | Inter Playa | - | Sporting Canamy | 7:1 | |
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| 13. Round | 27/11/2021 | Escorpiones | - | Inter Playa | 0:5 |
Mexico