1. Round | 24/07/2021 | MFK Ružomberok | - | FK Senica | 0:0 | ||||
2. Round | 01/08/2021 | FK Senica | - | Spartak Trnava | 2:1 | ||||
3. Round | 06/08/2021 | Zlaté Moravce | - | FK Senica | 1:1 | ||||
4. Round | 14/08/2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
6. Round | 28/08/2021 | Tatran Liptovský Mikuláš | - | FK Senica | 1:2 | ||||
7. Round | 11/09/2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
8. Round | 18/09/2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
9. Round | 25/09/2021 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
10. Round | 02/10/2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
19. Round | 18/12/2021 | FK Senica | - | AS Trenčín | 1:0 | ||||
20. Round | 12/02/2022 | Slovan Bratislava | - | FK Senica | 5:0 | ||||
22. Round | 26/02/2022 | MFK Zemplín Michalovce | - | FK Senica | 0:1 |