| 1. Round | 03/07/2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:3 | ||||
| 2. Round | 09/07/2022 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 3:1 | ||||
| 6. Round | 30/07/2022 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:3 | ||||
| 7. Round | 07/08/2022 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 2:2 | ||||
| 11. Round | 28/08/2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 | ||||
| 13. Round | 06/09/2022 | CF América [U20] | - | Atlético San Luis [U20] | 5:0 | ||||
| 14. Round | 11/09/2022 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 3:0 |
Mexico