| 2. Round | 02/03/2025 | Vancouver Whitecaps | - | Los Angeles Galaxy | 2:1 | ||||
| 3. Round | 09/03/2025 | Vancouver Whitecaps | - | CF Montréal | 2:0 | ||||
| 4. Round | 16/03/2025 | FC Dallas | - | Vancouver Whitecaps | 0:1 | ||||
| 5. Round | 23/03/2025 | Vancouver Whitecaps | - | Chicago Fire | 1:3 |  |
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| 6. Round | 29/03/2025 | Toronto FC | - | Vancouver Whitecaps | 0:0 | ||||
| 7. Round | 06/04/2025 | Vancouver Whitecaps | - | Colorado Rapids | 2:0 | ||||
| 8. Round | 13/04/2025 | Vancouver Whitecaps | - | Austin FC | 5:1 | ||||
| 9. Round | 20/04/2025 | St. Louis City SC | - | Vancouver Whitecaps | 0:0 | ||||
| 10. Round | 27/04/2025 | Minnesota United FC | - | Vancouver Whitecaps | 1:3 | ||||
| 11. Round | 04/05/2025 | Vancouver Whitecaps | - | Real Salt Lake | 2:1 |  |
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| 15. Round | 25/05/2025 | Real Salt Lake | - | Vancouver Whitecaps | 2:3 | ||||
| 16. Round | 29/05/2025 | Vancouver Whitecaps | - | Minnesota United FC | 0:0 |
Mexico
Spain