| 2. Round | 19/09/2021 | Fortuna Düsseldorf [Youth] | - | FC Schalke 04 [Youth] | 0:1 | ||||
| 3. Round | 26/09/2021 | FC Schalke 04 [Youth] | - | Alemannia Aachen [Youth] | 5:0 | ||||
| 4. Round | 02/10/2021 | Bayer Leverkusen [Youth] | - | FC Schalke 04 [Youth] | 2:2 | ||||
| 6. Round | 24/10/2021 | Borussia Dortmund [Youth] | - | FC Schalke 04 [Youth] | 4:0 | ||||
| 8. Round | 28/11/2021 | Bor. Mönchengladbach [Youth] | - | FC Schalke 04 [Youth] | 1:1 | ||||
| 9. Round | 05/12/2021 | FC Schalke 04 [Youth] | - | VfL Bochum [Youth] | 0:1 | ||||
| 10. Round | 06/02/2022 | Preußen Münster [Youth] | - | FC Schalke 04 [Youth] | 1:3 | ||||
| 11. Round | 13/02/2022 | FC Schalke 04 [Youth] | - | Rot-Weiss Essen [Youth] | 1:2 |
England