| 1. Round | 07/08/2010 | SC Freiburg II | - | Hessen Kassel | 1:1 | ||||
| 2. Round | 12/08/2010 | Karlsruher SC II | - | SC Freiburg II | 1:1 | ||||
| 3. Round | 22/08/2010 | SC Freiburg II | - | SpVgg Greuther Fürth II | 4:1 |  |
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| 4. Round | 29/08/2010 | Eintracht Frankfurt II | - | SC Freiburg II | 3:1 | ||||
| 5. Round | 01/09/2010 | SC Freiburg II | - | FSV Frankfurt II | 1:4 | ||||
| 6. Round | 04/09/2010 | Wormatia Worms | - | SC Freiburg II | 0:5 | ||||
| 7. Round | 10/09/2010 | SC Freiburg II | - | FC Memmingen | 2:0 | ||||
| 8. Round | 17/09/2010 | SC Pfullendorf | - | SC Freiburg II | 0:1 | ||||
| 9. Round | 21/09/2010 | SC Freiburg II | - | SG Sonnenhof Großaspach | 0:2 | ||||
| 10. Round | 25/09/2010 | SV Darmstadt 98 | - | SC Freiburg II | 2:5 | |
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| 11. Round | 03/10/2010 | SC Freiburg II | - | Stuttgarter Kickers | 1:0 | ||||
| 15. Round | 07/11/2010 | SC Freiburg II | - | SV Wehen Wiesbaden II | 1:3 |  |
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| 16. Round | 13/11/2010 | SSV Ulm 1846 | - | SC Freiburg II | annull. | |
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| 17. Round | 21/11/2010 | SC Freiburg II | - | SpVgg Weiden | annull. | |
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| 18. Round | 07/12/2010 | SC Freiburg II | - | Karlsruher SC II | 2:1 | ||||
| 20. Round | 11/12/2010 | SC Freiburg II | - | Eintracht Frankfurt II | 0:3 |
Switzerland
Austria