| 1. Round | 25/06/2022 | Mineros de Zacatecas | - | Club Celaya | 1:0 | ||||
| 2. Round | 08/07/2022 | Club Celaya | - | Pumas Tabasco | 2:1 | ||||
| 3. Round | 15/07/2022 | Venados FC | - | Club Celaya | 3:2 | ||||
| 4. Round | 21/07/2022 | Club Celaya | - | Tapatío | 2:0 | ||||
| 5. Round | 27/07/2022 | Atlético La Paz | - | Club Celaya | 0:0 | ||||
| 6. Round | 03/08/2022 | Dorados de Sinaloa | - | Club Celaya | 0:1 | ||||
| 7. Round | 09/08/2022 | Club Celaya | - | Tepatitlán | 1:0 | ||||
| 8. Round | 18/08/2022 | Coyotes de Tlaxcala | - | Club Celaya | 0:1 | ||||
| 11. Round | 07/09/2022 | Club Celaya | - | Atlético Morelia | 2:0 |  |
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| 12. Round | 14/09/2022 | Cancún FC | - | Club Celaya | 0:4 |  |
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| 13. Round | 21/09/2022 | Club Celaya | - | Alebrijes de Oaxaca | 2:0 | ||||
| 14. Round | 25/09/2022 | Alacranes de Durango | - | Club Celaya | 1:1 | |
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| 15. Round | 28/09/2022 | Club Celaya | - | Atlante | 2:1 | |
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| 16. Round | 04/10/2022 | Leones Negros | - | Club Celaya | 0:2 | |
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| 17. Round | 16/10/2022 | Club Celaya | - | Correcaminos UAT | 0:3 |
Mexico