| 1. Round | 10/07/2022 | Atlético San Luis [Women] | - | CF Monterrey [Women] | 3:4 |  |
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| 2. Round | 18/07/2022 | Club Tijuana [Women] | - | Atlético San Luis [Women] | 2:0 | ||||
| 3. Round | 24/07/2022 | Atlético San Luis [Women] | - | Deportivo Guadalajara [Women] | 0:1 |  |
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| 4. Round | 28/07/2022 | Puebla FC [Women] | - | Atlético San Luis [Women] | 6:2 | |
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| 5. Round | 31/07/2022 | Atlético San Luis [Women] | - | Cruz Azul [Women] | 2:1 | ||||
| 6. Round | 06/08/2022 | Pumas UNAM [Women] | - | Atlético San Luis [Women] | 3:0 | ||||
| 11. Round | 11/09/2022 | Atlético San Luis [Women] | - | UANL Tigres [Women] | 1:5 | ||||
| 12. Round | 17/09/2022 | Atlas Guadalajara [Women] | - | Atlético San Luis [Women] | 2:3 | ||||
| 13. Round | 22/09/2022 | Atlético San Luis [Women] | - | CF América [Women] | 1:3 | ||||
| 14. Round | 25/09/2022 | Atlético San Luis [Women] | - | Gallos Blancos [Women] | 1:0 | |
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| 15. Round | 03/10/2022 | Mazatlán FC [Women] | - | Atlético San Luis [Women] | 1:3 | ||||
| 16. Round | 16/10/2022 | Atlético San Luis [Women] | - | Santos Laguna [Women] | 0:2 | ||||
| 17. Round | 24/10/2022 | Club Necaxa [Women] | - | Atlético San Luis [Women] | 0:2 | |
Mexico