| 5. Round | 08/08/2021 | Volgar Astrakhan | - | FK Kamaz | 0:1 | ||||
| 6. Round | 14/08/2021 | FK Krasnodar 2 | - | Volgar Astrakhan | 1:0 | ||||
| 8. Round | 29/08/2021 | Enisey Krasnoyarsk | - | Volgar Astrakhan | 2:2 | ||||
| 10. Round | 11/09/2021 | Spartak Moskva 2 | - | Volgar Astrakhan | 1:0 |  |
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| 11. Round | 15/09/2021 | Volgar Astrakhan | - | Alania Vladikavkaz | 1:1 | |
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| 12. Round | 19/09/2021 | Tekstilshchik Ivanovo | - | Volgar Astrakhan | 1:2 | ||||
| 14. Round | 29/09/2021 | SKA-Khabarovsk | - | Volgar Astrakhan | 1:0 | ||||
| 16. Round | 09/10/2021 | Volgar Astrakhan | - | Metallurg Lipetsk | 0:2 | |
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| 17. Round | 13/10/2021 | Baltika Kaliningrad | - | Volgar Astrakhan | 0:2 | |
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| 19. Round | 23/10/2021 | FK Tom Tomsk | - | Volgar Astrakhan | 2:1 | ||||
| 21. Round | 06/11/2021 | FK Neftekhimik | - | Volgar Astrakhan | 0:1 |
Russia