| 1. Round | 18/07/2021 | Khimik Dzerzhinsk | - | Enisey Krasnoyarsk 2 | 0:1 |  |
|||
| 2. Round | 24/07/2021 | Khimik Dzerzhinsk | - | FK Chertanovo | 0:0 | ||||
| 4. Round | 07/08/2021 | Khimik Dzerzhinsk | - | Olimp-Dolgoprudny 2 | 2:0 | ||||
| 5. Round | 15/08/2021 | Torpedo Vladimir | - | Khimik Dzerzhinsk | 1:1 | ||||
| 6. Round | 21/08/2021 | Khimik Dzerzhinsk | - | FK Kazanka Moskva | 1:2 | ||||
| 7. Round | 29/08/2021 | Dinamo Moskva 2 | - | Khimik Dzerzhinsk | 10:1 | ||||
| 8. Round | 04/09/2021 | Khimik Dzerzhinsk | - | FK Murom | 2:1 | ||||
| 21. Round | 10/11/2021 | Khimik Dzerzhinsk | - | Shinnik Yaroslavl | 2:2 |  |
|||
| 22. Round | 14/11/2021 | Enisey Krasnoyarsk 2 | - | Khimik Dzerzhinsk | 0:1 |
Russia