| 1. Round | 10/07/2021 | Spartak Moskva 2 | - | FK Krasnodar 2 | 0:0 | ||||
| 2. Round | 17/07/2021 | FK Krasnodar 2 | - | Alania Vladikavkaz | 1:3 | ||||
| 3. Round | 24/07/2021 | FK Krasnodar 2 | - | Tekstilshchik Ivanovo | 1:1 | ||||
| 4. Round | 31/07/2021 | FK Krasnodar 2 | - | Olimp-Dolgoprudny | 2:0 |  |
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| 5. Round | 08/08/2021 | SKA-Khabarovsk | - | FK Krasnodar 2 | 1:0 | ||||
| 8. Round | 29/08/2021 | Baltika Kaliningrad | - | FK Krasnodar 2 | 2:1 | ||||
| 14. Round | 29/09/2021 | FK Krasnodar 2 | - | Rotor Volgograd | 1:1 | ||||
| 15. Round | 03/10/2021 | FK Kamaz | - | FK Krasnodar 2 | 2:0 | ||||
| 19. Round | 23/10/2021 | FK Krasnodar 2 | - | Kuban Krasnodar | 1:2 | ||||
| 20. Round | 31/10/2021 | Alania Vladikavkaz | - | FK Krasnodar 2 | 2:1 | ||||
| 21. Round | 06/11/2021 | Tekstilshchik Ivanovo | - | FK Krasnodar 2 | 0:1 | |
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| 23. Round | 17/11/2021 | FK Krasnodar 2 | - | SKA-Khabarovsk | 3:1 | ||||
| 24. Round | 21/11/2021 | Volgar Astrakhan | - | FK Krasnodar 2 | 0:0 | ||||
| 25. Round | 27/11/2021 | FK Krasnodar 2 | - | Metallurg Lipetsk | 1:0 |
Russia