| 2. Round | 24/07/2021 | FK Tyumen | - | FK Novosibirsk | 0:3 |  |
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| 3. Round | 01/08/2021 | FK Amkar Perm | - | FK Tyumen | 1:1 | ||||
| 4. Round | 07/08/2021 | FK Tyumen | - | Spartak Tuymazy | 4:3 | ||||
| 5. Round | 18/08/2021 | Dinamo Barnaul | - | FK Tyumen | 0:1 | |
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| 6. Round | 21/08/2021 | Irtysh Omsk | - | FK Tyumen | 2:4 | ||||
| 7. Round | 29/08/2021 | FK Tyumen | - | Torpedo Miass | 8:1 | ||||
| 8. Round | 06/09/2021 | FK Orenburg 2 | - | FK Tyumen | 3:7 |  |
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| 10. Round | 18/09/2021 | Nosta Novotroitsk | - | FK Tyumen | 1:1 | ||||
| 11. Round | 26/09/2021 | Zenit Izhevsk | - | FK Tyumen | 0:4 | |
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| 12. Round | 30/09/2021 | Zvezda Perm | - | FK Tyumen | 3:0 | |
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| 14. Round | 10/10/2021 | FK Tyumen | - | Volga Ulyanovsk | 1:3 | ||||
| 15. Round | 17/10/2021 | Lada Tolyatti | - | FK Tyumen | 0:2 | ||||
| 16. Round | 23/10/2021 | FK Tyumen | - | Lada Tolyatti | 7:0 | |
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| 17. Round | 31/10/2021 | Volga Ulyanovsk | - | FK Tyumen | 3:2 | |
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| 19. Round | 09/11/2021 | FK Tyumen | - | Zvezda Perm | 0:0 | ||||
| 20. Round | 14/11/2021 | FK Tyumen | - | Zenit Izhevsk | 3:0 | ||||
| 21. Round | 03/04/2022 | FK Tyumen | - | Nosta Novotroitsk | 1:1 | ||||
| 24. Round | 24/04/2022 | Torpedo Miass | - | FK Tyumen | 0:3 | ||||
| 29. Round | 28/05/2022 | FK Novosibirsk | - | FK Tyumen | 0:4 |
Russia