| 1. Round | 23/07/2021 | FK Rostov [U20] | - | FK Sochi [U20] | 3:1 | ||||
| 5. Round | 13/08/2021 | Uor-5 Egorievsk [U20] | - | FK Rostov [U20] | 0:7 |  |
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| 6. Round | 20/08/2021 | FK Rostov [U20] | - | Akhmat Grozny [U20] | 5:0 | ||||
| 7. Round | 27/08/2021 | FK Chertanovo [U20] | - | FK Rostov [U20] | 0:3 | |
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| 9. Round | 17/09/2021 | Arsenal Tula [U20] | - | FK Rostov [U20] | 1:2 | ||||
| 10. Round | 24/09/2021 | FK Rostov [U20] | - | Uor-5 Egorievsk [U20] | 3:1 | |
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| 11. Round | 01/10/2021 | FK Sochi [U20] | - | FK Rostov [U20] | 1:3 | ||||
| 12. Round | 15/10/2021 | FK Rostov [U20] | - | FK Krasnodar [U20] | 1:0 | |
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| 14. Round | 29/10/2021 | FK Rostov [U20] | - | Arsenal Tula [U20] | 4:0 | ||||
| 15. Round | 06/11/2021 | Zenit St. Petersburg [U20] | - | FK Rostov [U20] | 2:1 |  |
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| 17. Round | 26/11/2021 | FK Rostov [U20] | - | FK Khimki [U20] | 3:1 | ||||
| 18. Round | 03/12/2021 | FK Rostov [U20] | - | FK Chertanovo [U20] | 0:2 | |
Russia