| 7. Round | 28/08/2021 | Zenit St. Petersburg 2 | - | FK Chita | 4:0 | ||||
| 15. Round | 10/10/2021 | FK Kairat Moskva | - | Zenit St. Petersburg 2 | 3:0 | ||||
| 16. Round | 14/10/2021 | Zenit St. Petersburg 2 | - | FK Krasava | 1:0 | ||||
| 17. Round | 19/10/2021 | FK Chita | - | Zenit St. Petersburg 2 | 1:0 | ||||
| 18. Round | 25/10/2021 | Zenit St. Petersburg 2 | - | FK Tver | 1:1 | ||||
| 21. Round | 10/11/2021 | Baltika Kaliningrad 2 | - | Zenit St. Petersburg 2 | 2:1 |
Russia