| 1. Round | 24/07/2021 | FK Dinamo Makhachkala | - | FK Druzhba | 3:0 | ||||
| 2. Round | 01/08/2021 | FK Druzhba | - | Rotor-2 Volgograd | 0:2 | ||||
| 3. Round | 07/08/2021 | FK Tuapse | - | FK Druzhba | 3:0 | ||||
| 4. Round | 15/08/2021 | FK Druzhba | - | FK SKA Rostov | 1:4 | ||||
| 5. Round | 21/08/2021 | Dinamo Stavropol | - | FK Druzhba | 1:2 | ||||
| 6. Round | 29/08/2021 | FK Druzhba | - | Chernomorets Novorossisk | 0:1 | ||||
| 7. Round | 04/09/2021 | FK Yessentuki | - | FK Druzhba | 2:1 |  |
|||
| 8. Round | 08/09/2021 | FK Druzhba | - | FK Biolog Novokubansk | 1:1 |  |
|
||
| 9. Round | 13/09/2021 | FK Legion Dynamo Makhachkala | - | FK Druzhba | 1:2 | ||||
| 12. Round | 03/10/2021 | FK Druzhba | - | FK Chayka | 0:2 | ||||
| 13. Round | 10/10/2021 | Anzhi Makhachkala | - | FK Druzhba | 0:0 | ||||
| 15. Round | 23/10/2021 | FK Druzhba | - | Alania-2 Vladikavkaz | 1:1 | |
|||
| 16. Round | 31/10/2021 | Kuban-Holding Pavlovskaya | - | FK Druzhba | 3:1 | |
|||
| 17. Round | 06/11/2021 | FK Druzhba | - | Forte Taganrog | 1:2 | |
|||
| 19. Round | 19/11/2021 | FK Druzhba | - | FK Tuapse | 1:0 | ||||
| 20. Round | 06/03/2022 | FK SKA Rostov | - | FK Druzhba | 1:0 | ||||
| 21. Round | 06/04/2022 | FK Druzhba | - | Dinamo Stavropol | 4:1 | ||||
| 28. Round | 30/04/2022 | FK Chayka | - | FK Druzhba | 3:0 | |
Russia