| 3. Round | 24/07/2021 | Baltika Kaliningrad | - | FK Orenburg | 1:1 | ||||
| 4. Round | 31/07/2021 | Akron Tolyatti | - | Baltika Kaliningrad | 0:0 | ||||
| 5. Round | 08/08/2021 | Baltika Kaliningrad | - | FK Neftekhimik | 0:0 | ||||
| 6. Round | 14/08/2021 | Rotor Volgograd | - | Baltika Kaliningrad | 1:1 | ||||
| 14. Round | 29/09/2021 | Tekstilshchik Ivanovo | - | Baltika Kaliningrad | 3:2 |  |
|||
| 16. Round | 09/10/2021 | SKA-Khabarovsk | - | Baltika Kaliningrad | 0:2 | |
|||
| 17. Round | 13/10/2021 | Baltika Kaliningrad | - | Volgar Astrakhan | 0:2 | ||||
| 20. Round | 31/10/2021 | Baltika Kaliningrad | - | FK Tom Tomsk | 4:0 | ||||
| 22. Round | 13/11/2021 | Baltika Kaliningrad | - | Akron Tolyatti | 2:0 | |
|||
| 23. Round | 17/11/2021 | FK Neftekhimik | - | Baltika Kaliningrad | 0:0 | ||||
| 24. Round | 21/11/2021 | Baltika Kaliningrad | - | Rotor Volgograd | 2:1 | ||||
| 25. Round | 27/11/2021 | Baltika Kaliningrad | - | FK Kamaz | 0:0 |
Russia