| 1. Round | 18/07/2021 | Nosta Novotroitsk | - | Spartak Tuymazy | 1:2 | ||||
| 2. Round | 24/07/2021 | FK Ural 2 | - | Nosta Novotroitsk | 2:1 | ||||
| 3. Round | 04/08/2021 | Nosta Novotroitsk | - | Irtysh Omsk | 1:4 | ||||
| 4. Round | 07/08/2021 | Nosta Novotroitsk | - | Dinamo Barnaul | 0:2 | ||||
| 6. Round | 21/08/2021 | Lada Tolyatti | - | Nosta Novotroitsk | 2:2 | ||||
| 7. Round | 29/08/2021 | Zvezda Perm | - | Nosta Novotroitsk | 2:0 | ||||
| 8. Round | 05/09/2021 | Nosta Novotroitsk | - | Zenit Izhevsk | 1:0 | ||||
| 9. Round | 12/09/2021 | Nosta Novotroitsk | - | FK Chelyabinsk | 0:3 | ||||
| 10. Round | 18/09/2021 | Nosta Novotroitsk | - | FK Tyumen | 1:1 | ||||
| 11. Round | 26/09/2021 | Nosta Novotroitsk | - | FK Novosibirsk | 0:1 |
Russia