| 21. Round | 03/04/2022 | Zvezda Perm | - | FK Orenburg 2 | 1:2 | ||||
| 22. Round | 11/04/2022 | FK Orenburg 2 | - | Lada Tolyatti | 3:2 | ||||
| 23. Round | 17/04/2022 | FK Tyumen | - | FK Orenburg 2 | 4:0 | ||||
| 24. Round | 24/04/2022 | Spartak Tuymazy | - | FK Orenburg 2 | 1:2 | ||||
| 25. Round | 30/04/2022 | FK Orenburg 2 | - | Volga Ulyanovsk | 2:3 | ||||
| 26. Round | 08/05/2022 | FK Orenburg 2 | - | FK Ural 2 | 2:2 | ||||
| 27. Round | 18/05/2022 | Irtysh Omsk | - | FK Orenburg 2 | 1:1 | ||||
| 28. Round | 21/05/2022 | Dinamo Barnaul | - | FK Orenburg 2 | 3:0 | ||||
| 30. Round | 04/06/2022 | Torpedo Miass | - | FK Orenburg 2 | 2:1 |
Russia